From Cape Town

When entering Knysna on the N2 (Knysna Main Street) drive until the 3rd set of traffic lights (Long Street).
Turn Right into Long Street.
Carry on with this road until you reach the Traffic Lights at Waterfront Drive/Long Street.
Continue over the bridge of Thesen Islands and enter Thesen Harbour Town.

From Port Elizabeth

When Entering Knysna on the N2 (Knysna Main Street) drive until you reach the 3rd set of traffic lights (Waterfront Drive).
Turn Left onto Waterfront drive.
Continue on Waterfront drive until you reach the 1st set of traffic lights at Waterfront drive/Long street.
Turn left at this intersection and drive over  the bridge of Thesen Islands and enter Thesen Harbour Town.